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KMID : 1377020190160050443
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Tissue Engineering and Regenerative Medicine
2019 Volume.16 No. 5 p.443 ~ p.450
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Near-Infrared Contrast Agents for Bone-Targeted Imaging
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Jung Jin-Seok
Jo Dan-Bi
Jo Ga-Young
Hyun Hoon
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Abstract
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Background: For the bone-specific imaging, a structure-inherent targeting of bone tissue recently has been reported a new strategy based on incorporation of targeting moieties into the chemical structure of near-infrared (NIR) contrast agents, while conventional methods require covalent conjugation of bone-targeting ligands to NIR contrast agents. This will be a new approach for bone-targeted imaging by using the bifunctional NIR contrast agents.
Methods: The goal of this review is to provide an overview of the recent advances in optical imaging of bone tissue, highlighting the structure-inherent targeting by developing NIR contrast agents without the need for a bone-targeting ligand such as bisphosphonates.
Results: A series of iminodiacetated and phosphonated NIR contrast agents for the structure-inherent targeting of bone tissue showed excellent bone-targeting ability in vivo without non-specific binding. Additionally, the phosphonated NIR contrast agents could be useful in the diagnosis of bone metastasis.
Conclusion: By developing bone-targeted NIR contrast agents, optical imaging of bone tissue makes it very attractive for preclinical studies of bone growth or real-time fluorescence guided surgery resulting in high potential to shift the clinical paradigms.
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KEYWORD
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Near-infrared fluorescence imaging, Contrast agents, Bone-targeted, imaging Image-guided surgery
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